Riboxin (Darnica) Inosine 10 ampules 5 ml

Pharmacological action

Riboxinum metabolic drug, refers to the precursors of ATP. It has anabolic, antiarrhythmic, antihypoxic and koronrodilatirtee action. Involved in the metabolism of glucose, activates metabolic processes in conditions of hypoxia, stimulates the activity of enzymes of the Krebs cycle and the synthesis of nucleotides. Activates metabolic processes in the myocardium, exerting a positive effect on metabolic processes in the heart muscle, increases strength of cardiac contractions, provides adequate relaxation of the heart muscle in diastole.

Reduces platelet aggregation and stimulates the regeneration of ischemic tissue. Improves the blood flow in the coronary vessels.

Riboxin is absorbed in the digestive tract, metabolized in the liver by the kidneys is excreted in small quantities.

Indications for use

Riboxin is used in complex therapy:

- Coronary artery disease (coronary insufficiency, myocardial infarction, cardiac arrhythmia);
- myocardiodystrophy;
- myocarditis;
- heart defects congenital and acquired;
- arrhythmias, caused by taking cardiac glycosides;
- coronary atherosclerosis;
- "pulmonary" heart; degenerative changes of cardiac muscle due to endocrine disease or severe physical stress;
- cirrhosis of the liver; acute and chronic hepatitis;
- drug and toxic liver damage;
- urokoproporfirii;
- open-angle glaucoma with normalized intraocular pressure.
 
Riboxin as medicines farmakonisi used in operations on isolated kidney.

Method of application

Inside Riboxin administered in a daily dose of 0.6-2.4 In the first two days - 1 tablet (capsule) 3-4 times a day. The third day of dosage (in the absence of allergic complications) increased to 1.2-2.4 grams per day. The duration of treatment from 4 weeks to 3 months. The drug is taken before a meal.
Riboxin in complex therapy of urokoproporfirii appoint 0.8 g / day in 4 divided doses, every day, for 1-3 months.
 
A solution of Riboxin for parenteral administration:

 For intravenous 2% solution of Riboxin diluted in 250 ml sodium chloride 0.9% solution or solution глюкозы5%.
Riboxin, intravenous (bolus or slow – 40-60 drops per minute) starting with 0.2 g once in the first day, the dosage was increased to 0.4 g 1-2 times a day (in the absence of allergic reactions). The course of treatment is 10-15 days.

For farmakonisi kidney from ischemia Riboxinum injected intravenously 10-15 minutes before occlusion of the artery of the kidney in a single-dose 1.2 g (60 ml, 2%), after the restoration of blood flow of 0.8 g (40 ml of a solution of Riboxin 2%).
In acute cardiac arrhythmias is allowed bolus of Riboxin in a dose of 200-400 mg.
 
Side effects

Riboxin is usually well tolerated. In some cases may experience allergic reactions: skin itching, urticaria, hyperemia of skin. In rare cases, may increase uric acid levels in the blood.

Contraindications

Gout, hypersensitivity to the drug, hyperuricemia.

Drug interactions

Riboxin when used in the complex therapy potentiates action of antianginal, antiarrhythmic and inotropic drugs.

Overdose

Cases of overdose in clinical application is not registered.
 
Release form

Riboxin the coated tablets:
1 tablet contains 0.2 g of inosine;
in a package of 10, 20, 30, 40, 50.
 
Riboxin capsules:

1 capsule contains 0.2 g of inosine;
in a package of 20, 30, 50.
 
Riboksin a solution for injections 2%:
10 ml of solution contain 200 mg of inosine;
pack of 10 vials, in ampoules 5 or 10 ml.
 
Storage conditions

Drug list B. Store in a dry place at temperature between 15-25 degrees Celsius. Keep away from direct sunlight.

Composition

Tablets: the active substance is inosine -200 mg .
Of the vial: the active substance is inosine 20 mg/ml .
 
Additionally

Chronic administration of high doses may increase gout.
Riboxin be wary appoint patients with renal failure.
Riboxin is not used as a means of emergency correction of cardiac disorders.

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