Order - DONA Glucosamine Sulfate - 20 box/1500mg

52.00€
Product Code: 20 box
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Dona glucosamine sulfate 1500mg

Pharmacological effect

Stimulator of regeneration of cartilage weave, has anti-catabolic, anabolic, chondroprotective, analgesic, anti-inflammatory effect. Active substance Dona – glucosamine is an aminosaccharide with a low molecular weight, a natural component of articular cartilage. Glucosamine promotes the synthesis of proteoglycans of synovial fluid cells of cartilage (hyaluronic acid and glycosaminoglycans), inhibits enzymes that cause destruction of cartilage tissue (phospholipase A2, collagenase, etc.), inhibits the formation of superoxide radicals, reduces the activity of enzymes of the lysosome. Due to the action of glucosamine the drug initiates the process of fixation of sulfur in the formation chondroitinase acid and has a positive effect on the normal processes of calcium deposits in the bone weave, and prevents the intrusion of the formation of glycosaminoglycans, which cause non-steroidal PVA, and protects the chondrocytes from the damaging effects of corticosteroids. In the formation of glycosaminoglycans during normal metabolic processes implicate the sulfonate groups and solitaire, located in the lateral chains, reserved of proteoglycans, are involved in maintaining the elasticity of cartilage tissue, helping to hold water in it. Don, filling the lack of endogenous glucosamine increases the permeability of the joint capsule and helps to restore normal enzymatic processes in cells of the articular cartilage and synovial membrane.

 

Don is completely and rapidly absorbed in the small intestine. After oral or intramuscular mounting easily penetrates the weave, mainly articular cartilage. The half-life of the drug is 68 hours. Decrease of clinical manifestations in patients receiving the dons usually begins by the end of the second week of therapy and the therapeutic effect persists for eight weeks after the end of treatment.

 

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